American businesses rake in trillions of dollars every year, with the biggest players boasting their status as a Fortune 500 company. However, the COVID-19 pandemic, the supply chain crisis and rising inflation have all created a significant impact on consumer spending. And these challenges aren't equally applied across industries with some, like health insurance and oil companies, faring better than others. Discover the top 50 American businesses making the big bucks, as ranked by Fortune's 500 list for 2022.